A general method for the synthesis of isatins: preparation of regiospecifically functionalized isatins from anilines was written by Hewawasam, Plyasena;Meanwell, Nicholas A.. And the article was included in Tetrahedron Letters in 1994.Related Products of 56619-93-3 This article mentions the following:
A new method has been developed for regiospecific conversion of substituted anilines to isatins. The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with di-Et oxalate to furnish an α-ketoester. Hydrolytic deprotection of the amino moiety is accompanied by cyclization to provide the isatin. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Related Products of 56619-93-3).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 56619-93-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem