Palladium-catalyzed aryl amination- heck cyclization cascade: a one-flask approach to 3-substituted indoles was written by Jensen, Thomas;Pedersen, Henrik;Bang-Andersen, Benny;Madsen, Robert;Joergensen, Morten. And the article was included in Angewandte Chemie, International Edition in 2008.HPLC of Formula: 56619-93-3 This article mentions the following:
A Pd/dppf-based catalyst provides access to the title compounds from 1,2-dihalogenated aromatic compounds and allylic amines in a single reaction flask. The initial aryl amination step occurs with excellent selectivity for the aryl iodide to ensure the formation of a single indole regioisomer, which can be functionalized in situ by N-arylation. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3HPLC of Formula: 56619-93-3).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.HPLC of Formula: 56619-93-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem