Synthesis and Bioactivity of Ophiofuranones A and B was written by Gillsch, Franziska;Zeng, Haoxuan;Baer, Sofia I.;Schrey, Hedda;Schobert, Rainer. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 105-13-5 This article mentions the following:
Ophiofuranones A (E isomer shown in graphic) and B (Z isomer), metabolites of the fungus Ophiosphaerella korrae, were synthesized in 16 steps and 12%/22% yield. The stereogenic centers were established by Sharpless dihydroxylations and epoxidation, the 1,3-dienes via Wittig or HWE olefinations. The rings were closed through Knoevenagel-type condensation and lactonization. The ophiofuranones proved nontoxic at relevant concentrations against tumor cells, fibroblasts, and various bacteria and fungi. Ophiofuranone A and the monocyclic precursors were weakly active against microbial biofilms. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Product Details of 105-13-5).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Product Details of 105-13-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem