Synthesis of 1,2-Disubstituted Benzimidazoles via Acceptorless Dehydrogenative Coupling Using Ru(II)-Arene Catalysts Containing Ferrocene Thiosemicarbazone was written by Ravindran N E, Aswathi;Sindhuja, Dharmalingam;Bhuvanesh, Nattamai;Karvembu, Ramasamy. And the article was included in European Journal of Inorganic Chemistry in 2022.Recommanded Product: 105-13-5 This article mentions the following:
The catalytic activity of Ru(II)-arene complexes containing ferrocene thiosemicarbazone (Fc-TSC) ligands was investigated toward the selective synthesis of 1,2-disubstituted benzimidazoles I [R = n-Pr, Ph, 4-MeOC6H4, etc.; X = H, 6-Cl, 5-Me, 6-Me] via acceptorless dehydrogenative coupling of diamines with primary alcs. A series of Ru(II)-p-cymene complexes II [R1 = H, Me, Ph, cyclohexyl] containing Fc-TSC ligands III were synthesized and characterized. From single crystal X-ray crystallog. studies, the mol. structures of III [R1 = cyclohexyl] and II [R1 = Ph] were confirmed. The influence of electronic effect of ligands on the catalytic activity of their complexes was studied. The activity of good performer i. e. II [R1 = Ph] was compared with that of its benzene counterpart IV. The catalysis was extended to aromatic, aliphatic and heterocyclic substituted primary alcs., and phenylenediamines with electron-donating or -withdrawing substituents. Overall, synthesis of 1,2-disubstituted benzimidazoles I was accomplished with good to moderate yields, with hydrogen and water as only byproducts. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Recommanded Product: 105-13-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem