Antibacterial and antibiofilm activity of coenzyme Q0 against Vibrio parahaemolyticus was written by Zheng, Xiaoying;Guo, Jialu;Rao, Huishan;Guo, Du;Huang, Yixiao;Xu, Yunfeng;Liang, Sen;Xia, Xiaodong;Shi, Chao. And the article was included in Food Control in 2020.Quality Control of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione This article mentions the following:
Coenzyme Q0 (CoQ0) demonstrates antineoplastic and anti-inflammatory properties; however, its antimicrobial and antibiofilm activities against Vibrio parahaemolyticus have not been extensively examined Thus, the aim of the current study was to investigate the antimicrobial and antibiofilm activities, along with the underlying mechanism, of CoQ0 against V. parahaemolyticus. The min. inhibitory concentrations (MICs) of CoQ0 against eight V. parahaemolyticus strains ranged from 4 to 16μg/mL, while V. parahaemolyticus treated with CoQ0 showed a longer lag phase compared with the untreated control. CoQ0 was effective in destroying cell membrane integrity and inducing morphol. changes in the cell. In addition, an antibiotic sensitivity assay showed that CoQ0 caused cell damage associated with DNA, RNA, and proteins. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) anal. confirmed the action of CoQ0 on destroying proteins or inhibiting proteins synthesis of V. parahaemolyticus. CoQ0 effectively inactivated V. parahaemolyticus in mature biofilm on stainless steel surfaces and inhibited V. parahaemolyticus in fresh shrimp. These findings suggested that CoQ0 could be used as a natural antimicrobial and antibiofilm agent to control V. parahaemolyticus in the seafood supply chain, thereby preventing seafood-associated infections. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Quality Control of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione).
2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Quality Control of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem