Estimation and identification of non-polar compounds in clarithromycin bulk drug by high-performance liquid chromatography was written by Gorski, R. J.;Morgan, D. K.;Sarocka, C.;Plasz, A. C.. And the article was included in Journal of Chromatography in 1991.Reference of 1132-95-2 This article mentions the following:
A HPLC method was developed to estimate and identify the non-polar related substances and process impurities that elute after N-dimethyl-N-formyl-6-O-methylerythromycin A in clarithromycin (I) bulk drug. This method separates at least 15 compounds from the I peak. All of the non-polar compounds can be detected at the 0.02% (weight/weight) level. Five bulk drug lots were examined for late-eluting compounds The total related substances ranged from <0.10 to <0.25%. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Reference of 1132-95-2).
1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Reference of 1132-95-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem