Synthesis of substituted 2-[bis(4-hydroxyphenyl)methyl]pyridines was written by Schulz, Otto Erich;Fedders, Soenke. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1977.Safety of (6-Methoxypyridin-2-yl)methanol This article mentions the following:
The title compounds I (R = H, R1 = 5-Me, 4-Me, 3-Me, 4-OMe, 4-Cl, 4-OCH2Ph, 4-OH, 6-OMe; R = Ac, R1 = 3-Me, 4-OMe, 4-Cl) were prepared by treating 2-methylpyridine N-oxides with Ac2O, hydrolyzing 2-acetoxymethylpyridines, oxidizing 2-hydroxymethylpyridines with SeO2, and treating 2-formylpyridines with PhOH in the presence of H2SO4. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Safety of (6-Methoxypyridin-2-yl)methanol).
(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of (6-Methoxypyridin-2-yl)methanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem