Dual thermo-responsive amphiphilic alternating copolymers: one-pot synthesis and the temperature-induced self-assembly was written by Rao, Zi-Kun;Ni, Hai-liang;Liu, Yu;Li, Yang;Zhu, Hong-Yu;Hao, Jian-Yuan. And the article was included in Journal of Materials Science in 2020.Safety of 2-(2-Methoxyethoxy)ethanol This article mentions the following:
Abstract: Synthesis and self-assembly of stimuli-responsive amphiphilic alternating copolymers (AAC) are an emerging land of tremendous possibilities. Herein, by combining backbone polyethylene glycol (PEG) with pendent oligo-polyglycol simultaneously, two alternating LCST segments are knitted through enzymic synthesis, giving a series of alternating poly[(PEG400-a-succinic acid)-co-(diol(3EG)-a-succinic acid)] (PPSDS) for the first time. All the PPSDSs show only one-step sharp temperature responsiveness in transmittance-temperature curve owing to stabilization effect of PEG400. The cloud points can be linearly controlled by simply adjusting the feeding ratio of PEG400/diol-3EG. Referring to published works and 1H-NMR spectra in D2O, all the obtained AAC formed penetrable nanovesicles under 4鎺矯. The TEM and 1H-NMR results confirmed that when heated to 18鎺矯, PPSDS of “9/1” transformed from nanovesicles to large-compound micelles due to large hydrophobic volume, while other PPSDS of “8/2, 7/3, 6/4” retained the vesicle structures, except that the hydrophilic layer turned from PEG400 + diol(3EG) to PEG400 alone, leading to the size reduction The temperature-controlled size “expansion and contraction” of nanovesicles was unique for AAC, which was potentially good for enhancing loading rate. Further heating above cloud point resulted in the destruction of nanostructures and irregular intermol. aggregations. The first reported dual temperature-responsive AAC was innovative in structure design, providing a potential opportunity for the design and synthesis of controllable self-assemble structures and smart biomacromols. in biomedical applications. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Safety of 2-(2-Methoxyethoxy)ethanol).
2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of 2-(2-Methoxyethoxy)ethanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem