On February 10, 2022, Lee, Hiu-Fung; Lacbay, Cyrus M.; Boutin, Rebecca; Matralis, Alexios N.; Park, Jaeok; Waller, Daniel D.; Guan, Tian Lai; Sebag, Michael; Tsantrizos, Youla S. published an article.Safety of 1-Fluoro-2-methoxybenzene The title of the article was Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. And the article contained the following:
Novel analogs of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and exhibit antimyeloma activity in vivo. A key structural element of these inhibitors is a linker moiety that connects their (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)bisphosphonic acid core to various side chains. The structural diversity of this linker moiety, as well as the side chains attached to it, was investigated and found to significantly impact the toxicity of these compounds in MM cells. The most potent inhibitor CML-07-119(13c)(I) was evaluated in mouse and rat for liver toxicity and systemic exposure, resp., providing further optimism for the potential value of such compounds as human therapeutics. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Safety of 1-Fluoro-2-methoxybenzene
The Article related to multiple myeloma antimyeloma liver toxicity thienopyrimidine hggpps inhibitor pharmacokinetics, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Safety of 1-Fluoro-2-methoxybenzene
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Ether | (C2H5)2O – PubChem