Access to chromone-3-carboxylic acid via silver mediated coupling of 4-hydroxy coumarin and enol ester was written by Mishra, Priyadarshini;Sepay, Nayim;Panda, Niranjan. And the article was included in Tetrahedron Letters in 2021.Application In Synthesis of 4-Benzyloxyphenol The following contents are mentioned in the article:
A silver-mediated aerobic approach to access 2-methyl-chromone-3-carboxylic acids from the reaction of 4-hydroxycoumarins and enol esters in the presence of base was presented. Mechanistic investigation suggested that the base induced Michael-type addition reaction of 4-hydroxycoumarins to the enol esters resulting the sequential ring opening and closing with the liberation of acetone were the key-steps for the overall transformation. Theor. calculation of energy of the intermediates by DFT supported the proposed reaction mechanism. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application In Synthesis of 4-Benzyloxyphenol).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 4-Benzyloxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem