Metabolism of N-acylated and O-alkylated drugs by intestinal microflora during anaerobic incubation in vitro was written by Smith, G. E.;Griffiths, L. A.. And the article was included in Xenobiotica in 1974.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:
Phenacetin [62-44-2] and derivatives of acetanilide were N-deacylated by rat cecal microflora, the deacylation of the latter being dependent on the nature and position of the substituents. Thus, p-alkylated or o-, m-, or p-hydroxylated derivatives were deacylated, whereas a p-aromatic or halide substituent or an aromatic acyl grouping prevented deacylation. A few O-alkylated compounds with a simple benzenoid structure were dealkylated by cecal microflora, but none of the N-alkylated drugs were dealkylated. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem