Study on synthetic process of 4-bromine-2,6-difluorine-trifluorinemethoxybenzene was written by Qi, Su-zhong;Shi, Jun-jie;Chen, Ya-peng;Li, Jing. And the article was included in Meitan Yu Huagong in 2013.Application In Synthesis of 4-Bromo-2,6-difluoroanisole This article mentions the following:
A synthetic method of 4-bromine-2,6-difluorine-trifluorinemethoxybenzene was provided using 3,4,5-trifluorinebromobenzene as raw material through substitution reaction, dealkylation reaction, trifluoromethylation reaction, and finally the target product 4-bromine-2,6-difluoro-trifluoromethoxybenzene was gotten. This method had the characteristics which were the synthetic process was simplified, synthetic technol. was reasonable, synthetic steps were shorter, the yield of target product was high, the cost was low, the synthetic process was conductive to large-scale industrial production etc. Therefore, the synthesis method was suitable for large scale preparation of target compounds In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-difluoroanisole (cas: 104197-14-0Application In Synthesis of 4-Bromo-2,6-difluoroanisole).
4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application In Synthesis of 4-Bromo-2,6-difluoroanisole
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem