Synthesis of the benzofuran analog of ILV, a new protein kinase C (PKC) activator was written by Kozikowski, Alan P.;Ma, Dawei;Du, Linh;Lewin, Nancy E.;Blumberg, Peter M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1994.Computed Properties of C12H17NO2 This article mentions the following:
To probe the effect of small structural changes on the PKC activity of the natural product indolactam V (ILV), a synthesis of its benzofuran analog was developed. This compound was similar in its activity to ILV, exhibiting a Ki of 17.3 nM in the displacement of [3H]PDBU from PKCα. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Computed Properties of C12H17NO2).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Computed Properties of C12H17NO2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem