A Novel Ligand-free Manganese-catalyzed C-O Coupling Protocol for the Synthesis of Biaryl Ethers was written by Rohit, K. R.;Saranya, Salim;Harry, Nissy Ann;Anilkumar, Gopinathan. And the article was included in ChemistrySelect in 2019.Application of 54916-28-8 This article mentions the following:
Manganese catalyst was employed for the first time in the synthesis of biaryl ethers using various aryl alcs. and electron deficient aryl iodides as the coupling partners. This protocol does not require any ligand and employs relatively cheap, less toxic and easy to handle manganese chloride tetrahydrate as the metal catalyst. Aryl iodides having electron withdrawing groups provide a wide range of substrate scope for different phenols with moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Application of 54916-28-8).
1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application of 54916-28-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem