Synthesis and Structure-Activity Relationships of Novel 8a-Aza-8a-homoerythromycin A Ketolides was written by Pavlovic, Drazen;Mutak, Stjepan. And the article was included in Journal of Medicinal Chemistry in 2010.HPLC of Formula: 1132-95-2 This article mentions the following:
A series of novel 6-O-substituted 8a-aza-8a-homoerythromycin A ketolides was synthesized and evaluated for in vitro antibacterial activity. Key strategic elements of the synthesis include the base-induced E-Z isomerization of 3-O-descladinosyl-6-O-allylerythromycin A 9(E)-oxime followed by ring-expanding reaction of the resulting 9(Z)-oxime via Beckmann rearrangement. The ketolides showed potent activity against a variety of erythromycin-susceptible and macrolide-lincosamide-streptogramin B (MLSB) resistant Gram-pos. and fastidious Gram-neg. pathogens. The best compounds in this series overcome all types of resistance in relevant clin. Gram-pos. pathogens and display in vitro activity comparable to telithromycin and cethromycin. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2HPLC of Formula: 1132-95-2).
1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 1132-95-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem