A convenient method for [14C]-carbonylation reactions was written by Elmore, Charles S.;Dean, Dennis C.;Melillo, David G.. And the article was included in Journal of Labelled Compounds & Radiopharmaceuticals in 2000.Related Products of 75581-11-2 This article mentions the following:
A simple, efficient method for generation of 14CO from Ba14CO3 was developed. Reduction of 14CO2 using LiBEt3H gave lithium [14C]-formate in good yield which was treated with concentrate H2SO4 to effect dehydration to 14CO. Through direct attachment of a reaction vessel containing aryl substrate and Pd(0) catalyst, [14C]-carbonylation reactions were performed without use of a mercury transfer pump. [14C]-Carbonylation reactions using 14CO generated in this manner proceed in good yield with a variety of substrates. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Related Products of 75581-11-2).
4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Related Products of 75581-11-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem