Efficient and Mild Ullmann-Type N-Arylation of Amides, Carbamates, and Azoles in Water was written by Bollenbach, Maud;Aquino, Pedro G. V.;de Araujo-Junior, Joao Xavier;Bourguignon, Jean-Jacques;Bihel, Frederic;Salome, Christophe;Wagner, Patrick;Schmitt, Martine. And the article was included in Chemistry – A European Journal in 2017.Category: ethers-buliding-blocks This article mentions the following:
Aryl iodides underwent chemoselective Ullman coupling reactions with primary amides, tert-Bu carbamate, and azoles to yield N-aryl amides and carbamates and arylazoles using CuBr2 as a catalyst, trans-N,N’-dimethyl-1,2-cyclohexanediamine as ligand, D-glucose as a reductant, and NaOt-Bu as base in water containing the surfactant TPGS-750-M to yield N-aryl amides, tert-Bu arylcarbamates, and arylazoles. The surfactant and catalyst were recycled twice with some decrease in yield; in two cases, the reactions were purified without chromatog. by extraction with iso-Pr acetate, filtration through cotton and wool, concentration, dilution with isopropanol, and precipitation In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Category: ethers-buliding-blocks).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem