Phytochemical, antimicrobial and mast cell stabilizing activity of ethanolic extract of Solanum trilobatum Linn. leaves was written by Parasuraman, Subramani;Ren, Lee Yu;Chuon, Bobby Lau Chik;Yee, Stephanie Wong Kah;Qi, Tan Ser;Ching, Jan Yong Shu;Christapher, Parayil Varghese;Venkateskumar, Krishnamoorthy;Raj, Palanimuthu Vasanth. And the article was included in Malaysian Journal of Microbiology in 2016.SDS of cas: 6972-61-8 This article mentions the following:
Aims:Solanum trilobatum Linn., (Solanaceae) is one of the most widely used plants as food supplement in southern part of India and some parts of Southeast Asia. This plant is traditionally used for the treatment of respiratory illness. In animal studies, the extract of S. trilobatum showed significant antimicrobial, hepatoprotective and anticancer activities. The complete phytochem. profile, antimicrobial and mast cell stabilizing activities of S. trilobatum remains unclear. This study tests the antimicrobial, antihistaminic and mast cell stabilizing activities of ethanolic extract of leaves of S. trilobatum (EEST). Methodol. and results: The phytochem. test was carried out using chem. and instrumental [Gas Chromatog. Mass Spectrometry (GC-MS)] anal. methods. Antimicrobial effect of EEST was tested against Streptococcus pneumonia, Escherichia coli and Staphylococcus aureus. Intestinal mesentery of Sprague Dawley (SD) rats was used to study the peritoneal mast cell stabilization activity of EEST. The rat intestinal mesentery was exposed to 50, 100, 200, 300, 400 and 600 μg/mL of EEST and the peritoneal mast cell stabilization activity was compared with that of standards (pheniramine 20 μg/mL and ketotifen 20 μg/mL). The phytochem. test showed the presence of carbohydrates, saponins, flavonoids, alkaloids, tannins and phenolic compounds GC-MS anal. indicated the presence of 45 fragmented compounds which included epoxylinalol, himachalol, illudol, epibuphanamine, baimuxinal and edulan IV. EEST exhibited antimicrobial activity at 10 mg/mL against S. aureus, S. pneumonia. Significant mast cell stabilizing activity was observed from the dose of 100 μg/mL to 600 μg/mL. Conclusion: Ethanolic extract of leaves of S. trilobatum possess significant antimicrobial and antihistaminic activity. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8SDS of cas: 6972-61-8).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 6972-61-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem