Molecularly Responsive Binding through Co-occupation of Binding Space: A Lock-Key Story was written by Awino, Joseph K.;Hu, Lan;Zhao, Yan. And the article was included in Organic Letters in 2016.Computed Properties of C9H13ClN2O2 This article mentions the following:
When two guest mols. co-occupy a binding pocket of a water-soluble host, the first guest could be used as a signal mol. to turn on the binding of the second. This type of molecularly responsive binding strongly depends on the size of the two guests and the location of the signal mol. In the experiment, the researchers used many compounds, for example, 3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6Computed Properties of C9H13ClN2O2).
3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Computed Properties of C9H13ClN2O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem