Stereoselective synthesis of 3,4-trans-disubstituted γ-lactams by cerium(IV) ammonium nitrate mediated radical cyclization of cinnamamides was written by Nair, Vijay;Mohanan, Kishor;Suja, Tachapully D.;Biju, Akkattu T.. And the article was included in Synthesis in 2007.Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:
A facile synthesis of 3,4-trans-disubstituted γ-lactams, e.g., I, was developed, consisting of the radical cyclization of cinnamamides mediated by cerium(IV) ammonium nitrate. The single-electron-transfer reaction of the methoxystyrenyl moiety mediated by cerium(IV) ammonium nitrate gives rise to a cation radical, whose cyclization followed by reaction with oxygen and methanol generates 3,4-trans-disubstituted γ-lactams. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 3-(2,4-Dimethoxyphenyl)acrylic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem