Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083 was written by Xie, Hexin;Zhang, Yinan;Zhang, Shilei;Chen, Xiaobei;Wang, Wei. And the article was included in Angewandte Chemie, International Edition in 2011.Reference of 56619-93-3 This article mentions the following:
A novel highly efficient bifunctional cinchona alkaloid thiourea catalyzed enantioselective aza-Henry reaction of trifluoromethylquinazolinones with nitromethanes is reported. The reaction provides enantioenriched trifluoromethyl nitromethyl dihydroquinazolinones in good yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Reference of 56619-93-3).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Reference of 56619-93-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem