Phase transfer-catalyzed reactions of benzylidenebenzylamine with cinnamic acid derivatives. Synthesis of β-aryl-γ-phenyl-γ-aminobutyric acids and their derivatives was written by Potapov, V. M.;Gracheva, R. A.;Sivova, N. A.. And the article was included in Zhurnal Organicheskoi Khimii in 1989.Related Products of 6972-61-8 This article mentions the following:
Knoevenagel reaction of RCHO [R = 4-BrC6H4, 4-ClC6H4, 4-tolyl, 2- and 4-MeOC6H4, 4-O2NC6H4, 2,4- and 3,4-(MeO)2C6H3] with CH2(CO2H)2 in pyridine containing piperidine gave 46-90% RCH:CHCO2H (same R), which were esterified in EtOH containing H2SO4 to give 59-75% RCH:CHCO2Et (same R) (I). PhCH:CHCOEt reacted with SOCl2 in C6H6 containing pyridine and then with R1OH [R1 = (-)-menthyl, Bu, Me2CH, cyclohexyl] in pyridine to give 60-92% PhCH:CHCO2R1 (II; same R1). PhCH:NCH2Ph added to I and II in MeCN containing 50% aqueous NaOH and PhCH2NEt3+ Cl– to give 8 corresponding HO2CCH2CHRCHPhNH2.HCl (III.HCl) in 37-93% yield after refluxing with 4N HCl in C6H6. Passing III.HCl [R = Ph, 4-O2NC6H4, 4-tolyl, 4-MeO6H4, 3,4-(MeO)2C6H3] through a Dowex-50 × 4 column gave 70-85% free III (same R). Refluxing III.HCl [R = H, 3,4-(MeO)2C6H3, 4-BrC6H4, 4-ClC6H4] in C6H6 containing aqueous NaHCO3 gave 68-72% lactams IV (same R), which returned III.HCl quant. after refluxing with concentrated HCl. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Related Products of 6972-61-8).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 6972-61-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem