The amide C-N bond of isatins as the directing group and the internal oxidant in Ru-catalyzed C-H activation and annulation reactions: access to 8-amido isocoumarins was written by Kaishap, Partha Pratim;Sarma, Bipul;Gogoi, Sanjib. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Application In Synthesis of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene This article mentions the following:
The use of the amide C-N bond of isatins as the oxidizing directing group for the Ru(II)-catalyzed redox-neutral C-H activation and annulation reactions with alkynes which afford 8-amido isocoumarins were reported. The reaction also featureed excellent regioselectivity with alkyl aryl substituted alkynes. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Application In Synthesis of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene).
1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem