Catalytic amination in the synthesis of hybrid polymacrocycles comprising porphyrin and azacrown ether moieties was written by Yakushev, Alexei A.;Averin, Alexei D.;Maloshitskaya, Olga A.;Syrbu, Sergei A.;Koifman, Oskar I.;Beletskaya, Irina P.. And the article was included in Mendeleev Communications in 2016.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:
Pd0-catalyzed amination of 3-bromobenzyl-substituted azacrown ethers with propane-1,3-diamine affords the 3-(3-aminopropyl)benzyl derivatives, whose reaction with meso-(bromophenyl)-substituted porphyrins leads to bis- and trismacrocyclic conjugates. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).
1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem