Hydroxytetraphenylenes as Chiral Ligands: Application to Asymmetric Darzens Reaction of Diazoacetamide with Aldehydes was written by Chai, Guo-Li;Han, Jian-Wei;Wong, Henry N. C.. And the article was included in Synthesis in 2017.Application of 56619-93-3 This article mentions the following:
Hydroxytetraphenylenes with rigid conformations are potential candidates for employment as chiral ligands in asym. synthesis. Highly diastereo- and enantioselective Darzens reactions between aldehydes and diazo-N,N-dimethylacetamide are catalyzed by a chiral titanium complex formed in situ from Ti(OiPr)4 and chiral 1,16-dihydroxytetraphenylene, giving cis-glycidic amides in moderate to high yields with excellent enantiomeric purities (40-99% yield, up to 99% ee). In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application of 56619-93-3).
N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Application of 56619-93-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem