Palladium-Catalyzed Intermolecular C(sp3)-H Amidation was written by Iglesias, Alvaro;Alvarez, Rosana;de Lera, Angel R.;Muniz, Kilian. And the article was included in Angewandte Chemie, International Edition in 2012.Recommanded Product: 4-Iodo-1-methoxy-2-methylbenzene This article mentions the following:
Palladium-catalyzed intermol. C(SP3)-H activation/amination of alkyl group to give amine derivatives, e.g. I [X = H, Br, Me, etc.], was reported. N-Fluorobis(phenylsulfonyl)imide (NSFI) was identified as the decisive reagent for the development of a new palladium-catalyzed oxidative amidation od C(SP3)-H bonds. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Recommanded Product: 4-Iodo-1-methoxy-2-methylbenzene).
4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 4-Iodo-1-methoxy-2-methylbenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem