Synthesis of 5-methoxyindole was written by He, Zhi-yong;Fan, Bi-you. And the article was included in Jiangsu Huagong in 2005.Category: ethers-buliding-blocks This article mentions the following:
Four kinds of synthetic methods of 5-methoxyindole (FMI) are discussed and compared with each other. The 5-bromoindole (FBI) route is economical and effective. The optimum material compounding ratio is obtained by experiment: m(FBI):m(CatB):m(CH3ONa):m(DMF) = 1:0.83:9.75:8.7, FMI is gained by method of direct distillation in later disposal, the yield of product can be reached 78.8% with purity of 99.96%. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Category: ethers-buliding-blocks).
3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem