Ma, Mingxuan et al. published their research in Chromatographia in 2017 | CAS: 66943-05-3

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 66943-05-3

Preparation and Application of Aza-15-crown-5-capped Methylcalix[4]resorcinarene-Bonded Silica Particles for Use as Chiral Stationary Phase in HPLC was written by Ma, Mingxuan;Wei, Qunli;Meng, Min;Yin, Jiale;Shan, Yu;Du, Lei;Zhu, Xia;Soh, Shu Fang;Min, Mengjun;Zhou, Xueyan;Yin, Xiaoxing;Gong, Yinhan. And the article was included in Chromatographia in 2017.HPLC of Formula: 66943-05-3 This article mentions the following:

Abstract: Aza-15-crown-5-capped (3-(C-methylcalix[4]resorcinarene)-2-hydroxypropoxy)-propylsilyl (MCR-HP)-appended silica particles (15C5-MCR-HPS), a new type of substituted C-methylcalix[4]resorcinarene (MCR)-bonded chiral stationary phase (CSP) for high-performance liquid chromatog. (HPLC), have been synthesized by reaction of bromoacetate-substituted MCR-HPS with excessive aza-15-crown-5 in anhydrous acetonitrile in the presence of potassium carbonate. The bonded phase 15C5-MCR-HPS is characterized by elemental anal. and further evaluated by separating several disubstituted benzenes and some chiral drug compounds in HPLC. The new CSP has a chiral selector with two recognition sites: 15-crown-5 and MCR-HP, which can provide cooperative multiple interactions with solutes to enhance chiral recognition and to improve chromatog. separation The chromatog. evaluation results show that 15C5-MCR-HPS has excellent selectivity for the separation of aromatic positional isomers and enantiomers of some chiral compounds under multiple-mode mobile phase conditions including normal phase, reversed phase, and polar organic mobile phase conditions. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem