Polymer-assisted solution-phase synthesis under combined ultrasound and microwave irradiation. Preparation of α,β-unsaturated esters and carboxylic acids, key intermediates of novel sigma ligands was written by Rossi, D.;Urbano, M.;Baraglia, A. Carnevale;Serra, M.;Bergamelli, F.;Iannelli, M.;Azzolina, O.;Collina, S.. And the article was included in Synthetic Communications in 2009.Recommanded Product: 6972-61-8 This article mentions the following:
The optimal conditions to prepare α,β-unsaturated Me esters via Wittig reaction combining polymer-assisted solution-phase synthesis (PASPS) methodol. and simultaneous ultrasound and microwave irradiation were established. The effects of temperature, solvent, and irradiation time were discussed. Results clearly indicated the superiority of combined ultrasound and microwave-assisted procedure over microwave-assisted methodol. Moreover, an efficient PASPS procedure to prepare α,β-unsaturated carboxylic acids via tandem Wittig olefination and hydrolysis reaction was developed under combined ultrasound and microwave irradiation Generally, a good conversion of aldehydes to acids was observed The optimized protocols allowed us to quickly prepare a small collection of either α,β-unsaturated esters or carboxylic acids, key intermediates for the drug-discovery process of new sigma ligands. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).
3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem