Related Products of 109-85-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-85-3, name is 2-Methoxyethylamine, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 6-amino-4-fluoronicotinonitrile 7 (4.11 g, 30 mmol), 2-methoxyethanamine (4.5 g, 60 mmol), and DIPEA (1.16 g, 90 mmol) in DMF (120 mL) was stirred at 60C until the reaction was completed by TLC. After quenched with water, the reaction solution was extracted with CH2Cl2 (3 ×100 mL), washed with sequentially with satd NaHCO3 (aq) and brine and then dried over anhydrous Na2SO4. Filtration, evaporation, and chromatography on silica gel afforded the product 8 (3.84 g, 67%). MS m/z (ESI): 193.1 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 2-Methoxyethylamine. I believe this compound will play a more active role in future production and life.
Reference:
Article; Sun, Chang’an; Fang, Lei; Zhang, Xiaobing; Gao, Peng; Gou, Shaohua; Bioorganic and Medicinal Chemistry; vol. 27; 10; (2019); p. 1932 – 1941;,
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