Synthetic Route of 19500-02-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19500-02-8 as follows.
A. N-tert-butoxycarbonyl-3-methoxy-2-methylaniline. By the method in Example 1, Part A, 25.8 g (188 mmol) of 3-methoxy-2-methylaniline was treated with 41 g (188 mmol) of di-tert-butyl dicarbonate to give by chromatography on silica (eluted with 25percent EtOAc/hexane) 16.4 g (80percent yield) of N-tert-butoxycarbonyl-3-methoxy-2-methylaniline. Analysis: Calc’d for C13 H19 NO3: C, 65.80; H, 8.07; N, 5.90. Found: C, 64.31; H, 7.76; N, 6.58.
According to the analysis of related databases, 19500-02-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Eli Lilly and Company; US5684034; (1997); A;,
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