Synthetic Route of 60792-79-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60792-79-2 name is 2,2′-Oxybis(ethylamine) dihydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Vancomycin (16.0 g, 11.2 mmol, 1.0 eq) was dissolved in [H20] (100 mL) and treated with a solution of 5-amino-3-oxo-pentylamine dihydrochloride salt (10.0 g, [56] mmol, 5 eq) in H2O [(30] mL) and the reaction mixture was stirred at ambient temperature. Triethylamine (22 mL, 160 mmol) was then added, followed by an aqueous solution of formaldehyde (37%, 1. 05 mL, 11.2 mmol) and the reaction mixture was stirred at ambient temperature for one hour. The reaction mixture was diluted with water/acetonitrile (1: 1; 200 mL) and lyophilized. The resulting mixture was dissolved in H2O (50 mL) and purified using large scale HPLC (0-12% gradient over 40 minutes) to provide, after lyophilization, the title compound as a white amorphous powder (7.2 g). HPLC (2-30% gradient): 2.4 min. MS m/z : 1566.9 [M + H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2′-Oxybis(ethylamine) dihydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; THERAVANCE, INC.; WO2003/99858; (2003); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem