Synthetic Route of 645-36-3, A common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, molecular formula is C6H15NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2,2-Diethoxyethylamine (505 muL, 3.48 mmol) and Et3N (485 muL,3.48 mmol) were added to a soln of pyrimidine 3 (0.5 g, 2.32 mmol)in MeOH (25 mL), and the mixture was stirred at r.t. for 20 h. H2O(100 mL) was added and the precipitate was collected by filtration,dried, and crystallized (hexane) to give a colorless solid; yield: 0.62g (82%); mp 84-85 C.IR (KBr): 3320 (NH), 2220 (CN) cm-1.1H NMR (300 MHz, CDCl3): delta = 1.26 (t, J = 6.9 Hz, 6 H, 2 ¡Á CH3),2.53 (s, 3 H, SCH3), 3.58 (dq, 2J = 9.6 Hz, 3J = 6.9 Hz, 2 H,2 ¡Á CHAHBCH3), 3.69 (t, J = 5.4 Hz, 2 H, NCH2), 3.76 (dq, 2J = 9.6Hz, 3J = 6.9 Hz, 2 H, 2 ¡Á CHAHBCH3), 4.02 (s, 3 H, OCH3), 4.61 (t,J = 5.4 Hz, 1 H, OCH), 5.65 (t, J = 5.4 Hz, 1 H, NH).13C NMR (75 MHz, CDCl3): delta = 14.5, 15.6, 43.8, 54.9, 63.3, 70.6,100.7, 114.7, 162.8, 169.7, 175.6.Anal. Calcd for C13H20N4O3S: C, 49.98; H, 6.45. Found: C, 50.08;H, 6.59.
The synthetic route of 645-36-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Juskenas, Robertas; Masevicius, Viktoras; Tumkevicius, Sigitas; Synthesis; vol. 45; 17; (2013); p. 2438 – 2446;,
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