Lusi, Robert F.;Sennari, Goh;Sarpong, Richmond published 《Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy》. The research results were published in《Nature Chemistry》 in 2022.Computed Properties of C15H16O2 The article conveys some information:
Natural product total synthesis inspires the development of synthesis strategies to access important classes of mols. In the 1960s, Corey and coworkers demonstrated a visionary preparation of the terpenoid longifolene, using ‘strategic bond anal.’ to craft a synthesis route. This approach proposes that efficient synthesis routes to bridged, polycyclic structures should be formulated to introduce the bulk of the target’s topol. complexity at a late stage. Subsequently, similar strategies have proved general for the syntheses of a wide variety of bridged, polycyclic mols. Here, we demonstrate that an orthogonal strategy where topol. complexity is introduced at the outset leads to the short synthesis of the longifolene-related terpenoid longiborneol. To implement this strategy, we access a bicyclo[2.2.1] starting material through scaffold remodelling of readily available (S)-carvone. We also employ a variety of late-stage C-H functionalization tactics in divergent syntheses of many longiborneol congeners. Our strategy may prove effective for the preparation of other topol. complex natural products that contain the bicyclo[2.2.1] framework. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .
For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Computed Properties of C15H16O2
Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem