658-89-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 658-89-9 name is 4-(Trifluoromethoxy)benzene-1,2-diamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 3-isothiocyanato-N-methyl-3-[3-(trifluoromethyl)phenyl]propanamide (0.3 g, 1 mmol) (from step 3) and 4-(trifluoromethoxy)benzene-l,2-diamine (0.2 g, 1 mmol) in dichloromethane (100 mL) was stirred at ambient temperature. After 4 h, the reaction mixture was concentrated to afford the crude product (0.50 g) as yellow gum. It was purified by flash column using 230-400 silica gel, the product fraction was eluted using 40 % ethyl acetate in hexane to afford 3-({[2-amino-5- (trifluoromethoxy)phenyl]carbamothioyl} amino)-N-methyl-3 – [3 – (trifluoromethyl)phenyl]propanamide (0.4 g) as an off-white solid. MS: m/z 481 (M+l).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Trifluoromethoxy)benzene-1,2-diamine, and friends who are interested can also refer to it.
Reference:
Patent; ACESION PHARMA APS; S?RENSEN, Ulrik Svane; METE, Anthonio; (90 pag.)WO2019/34603; (2019); A1;,
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