As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 454-90-0 name is 3-(Trifluoromethyl)anisole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 454-90-0
General procedure: (b) For isolations of the major products, copper(I) chloride (0.248 g, 2.5 mmol) and Mg powder (0.486 g, 20 mmol) were stirred in DMI (20 ml, 10 ml for 7i, 7j, 7k) and TMS-Cl (5 ml, 40 mmol) for 15 min under an argon atmosphere. Then, a benzotrifluoride derivative 6 (5 mmol) was added dropwise over 5 min into the dark suspension. The solution was stirred for additional time (see Table 2), keeping the temperature 25 C (bath temperature, 50 C for 7i, 7j, 7k). After addition of 5 ml of hexane, Mg-Cu was removed by decantation and the suspension was simultaneously extracted with hexane (5 ml¡Á5). Then, the combined hexane layer was washed with 10 wt % HCl aq and brine. After drying over sodium sulfate, purification by column chromatography on silica gel (hexane eluent) and distillation afforded the product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)anisole, and friends who are interested can also refer to it.
Reference:
Article; Utsumi, Shinya; Katagiri, Toshimasa; Uneyama, Kenji; Tetrahedron; vol. 68; 4; (2012); p. 1085 – 1091;,
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