20265-97-8, These common heterocyclic compound, 20265-97-8, name is 4-Methoxyaniline hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
p-anisidine hydrochloride (0.01 mol) was dissolved in a solution of concentrated hydrochloric acid (0.02 mol) in 50 ml of water. The mixture was cooled to 273 K on an ice water bath, and then sodium nitrite (0.015 mol) was dissolved in a small amount of water and added dropwise with vigorous stirring. The reaction mixture was stirred for1h, and then ethylenediamine dihydrochloride (0.0025 mol) was added. After the intense stirring for 10 min, KOH (0.04 mol) in 100 ml of water was added dropwise.The reaction took place immediately, and, as a result, the solution changed its color.The precipitate was collected by the vacuum filtration and dried at room temperature in vacuum. Yield 80%.1H-NMR (400 MHz, DMSO-D6, d, ppm) 7.50 (d, 8H, Ar), 6.90 (d, 8H, Ar), 3.84 (s,12H, -CH3), 3.1 (s, 4H, -CH2-) IR (KBr): 3000, 2934, 1602, 1504, 1448, 1248, 1028, 834
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 20265-97-8.
Reference:
Article; Vyshnevsky, Dmitry; Syromyatnikov, Vladimir; Kolendo, Alexey; Molecular Crystals and Liquid Crystals; vol. 672; 1; (2018); p. 73 – 80;,
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