As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 157869-15-3 name is 2-((4-Methoxyphenyl)ethynyl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 157869-15-3
In 15 ml reaction tube are sequentially added into a 1 l (0.3 mmol, 67 mg), [RhCp * Cl2 ]2 (0.015 Mmol, 9.3 mg) and hexafluoroisopropanol (2 ml), in a nitrogen atmosphere of the reaction pipe sealing, in the 120 C stirring for 20 h. After the reaction, the reaction tube to be cooled to the room temperature, adding 10 ml water, then the extraction of ethyl acetate (10 ml ¡Á 3), after the organic phase with water and saturated salt water are successively washing, drying with anhydrous sodium sulfate. Filtering, turns on lathe does, too separating by silica gel column (petroleum ether/ethyl acetate=10/1) to yellow solid product 2 l (44 mg, 65%). The compound of the characterization data are as follows
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-((4-Methoxyphenyl)ethynyl)aniline, and friends who are interested can also refer to it.
Reference:
Patent; Henan Normal University; Fan Xuesen; Jia Ruixue; Zhang Xinying; Li Bin; (19 pag.)CN110105274; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem