Related Products of 41406-00-2, These common heterocyclic compound, 41406-00-2, name is 3-Isopropoxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 3-Chloro-4-fluoroaniline (172 mg, 1.18 mmol) was added to a solution of compound 12 (300 mg, 1.07 mmol) in isopropanol (10 mL) and refluxed for 8 h. The mixture was cooled to room temperature and filtered, the solid was washed with chill isopropanol (5 mL), the residue was treated with aqueous NaHCO3 (10 mL) and extracted with EtOAc/MeOH (20:1, 30 mL). The organic layer was washed with brine, dried over Na2SO4, and concentrated. Purified by silica-gel column chromatography (DCM/MeOH, 40/1), Rf = 0.25. Drying gave 358 mg (yield, 86%) of the title compound as white solid.
Statistics shows that 3-Isopropoxyaniline is playing an increasingly important role. we look forward to future research findings about 41406-00-2.
Reference:
Article; Yin, Siyuan; Zhou, Liliang; Lin, Jinsheng; Xue, Lingjing; Zhang, Can; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 462 – 475;,
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