Related Products of 7252-83-7,Some common heterocyclic compound, 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, molecular formula is C4H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
13. Alkylation step C [00257] In a 20 ml microwave vial containing III-2 (1 equivalent), alkyl halide (4 equivalents), KI (2 equivalents), and Cs2CO3 (2 equivalents) was added anhydrous DMF, 10 –>ml. This was heated under microwave conditions at 1200C for 60 minutes. The reaction was added to a seperatory funnel containing water and washed 3x with EtOAc. The combined organic layers were washed with saturated aqueous brine solution. The organic layer was dried with MgSU4 concentrated in vacuo. This was filtered through a silica plug, washed 3x with EtOAc, and concentrated in vacuo to yield III-3 (100 %). This material was used without further purification. 4-BROMO-N-(3-BROMO-4-(2,2-DIMETHOXYETHOXY)PHENETHYL)THIOPHENE-2- CARBOXAMIDE [00258] 1H NMR (400 MHz, DMSO-d6) delta 8.64 (t, J= 5.2 Hz, IH), 7.88 (s, IH), 7.75 (s, IH), 7.45 (d, J= 2.0 Hz, IH), 7.16 (dd, J= 8.4, 1.6 Hz, IH), 7.06 (d, J= 8.4, IH), 4.68 (t, J= 5.2 Hz, IH), 4.00 (d, J= 7.2 Hz, 2H), 3.42 (q, J= 6.0 Hz, 2H), 3.37 (s, 6H), 2.76 (t, J= 6.8 Hz, 2H).
The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VANDERBILT UNIVERSITY; WO2009/152071; (2009); A1;,
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