Electric Literature of 101-55-3, These common heterocyclic compound, 101-55-3, name is 1-Bromo-4-phenoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 10.0g (42.8mmol) 4- polybrominated diphenyl ethers dissolved in 100ml of tetrahydrofuran, cooled to -20 , dropping19.2ml (48.0mmol) of n-butyllithium, the reaction was kept 1 hour after dropwise. Then dropping 6.4g (36.0mmol)A compound of formula 3 was dissolved in 30ml of tetrahydrofuran, warmed to 0 deg.] C After the addition, the reaction was continued for 1 hour.Was added dropwise 50ml of saturated ammonium chloride solution, the organic phase was separated. The organic phase was concentrated to give a yellow solid 10.8g,Yield 86.4%.
Statistics shows that 1-Bromo-4-phenoxybenzene is playing an increasingly important role. we look forward to future research findings about 101-55-3.
Reference:
Patent; Okuura Dayton (Shanghai) Pharmaceutical Co., Ltd.; Yu, Libing; Guo, Maojun; Yang, Qingang; Ren, Huasen; (19 pag.)CN105622613; (2016); A;,
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