Reference of 4393-09-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Epoxide (0.5 mmol) was dissolved in absolute ethanol (10 mL), mixed with amine (1.1 mmol), heated to reflux (78C) overnight. If amine HCl salt, add DiPEA (1.1 mmol). If using microwave conditions, substitute isopropyl alcohol for solvent and microwave, 120C, 15 min. Note- Use ammonium hydroxide (conc., 9 eq) for unsubstituted amine addition.
The chemical industry reduces the impact on the environment during synthesis (2,3-Dimethoxyphenyl)methanamine. I believe this compound will play a more active role in future production and life.
Reference:
Article; Ross, Tina Morgan; Battista, Kathleen; Bignan, Gilles C.; Brenneman, Doug E.; Connolly, Peter J.; Liu, Jingchun; Middleton, Steven A.; Orsini, Michael; Reitz, Allen B.; Rosenthal, Dan I.; Scott, Malcolm K.; Vaidya, Anil H.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 3; (2015); p. 602 – 606;,
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