Synthetic Route of 20265-97-8, A common heterocyclic compound, 20265-97-8, name is 4-Methoxyaniline hydrochloride, molecular formula is C7H10ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 2-oxazolidinone (1.5 g, 17.2 mmol) in 2-(2-ethoxyethoxy)ethanol (20 mL) was treated with p-anisidine hydrochloride (2.1 g, 17.2 mmol) and heated in the microwave at 150 C. at 300 W for 10 min. The solution was cooled to rt and Et2O (50 mL) was added. The resulting solid precipitate was filtered and washed with Et2O (3¡Á20 mL). HPLC: Rt=0.23. MS (ESI): mass calcd. for C9H14N2O, 166.1; m/z found, 150 [M-16]+.
The synthetic route of 20265-97-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Allen, Darin; Choong, Ingrid; Lew, Willard; US2008/207683; (2008); A1;,
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