Application of 216067-66-2,Some common heterocyclic compound, 216067-66-2, name is O-(2,4-Dimethoxybenzyl)hydroxylamine, molecular formula is C9H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
INTERMEDIATE 3 Preparation of 5- (3-Formvl-ph)-furan-2-carboxylic acid 2 4-dimethoxv-benzyloxv)- amide The title compound was made by method analogous to INTERMEDIATE 2. Alternatively, it was also made by the following method. The acid (25) which was made by method analogous to INTERMEDIATE 1, was reacted with protected hydroxylamine (24) by using N, N’-Dicyclohexylcarbodiimide (DCC) as coupling reagent. The resulting bromide (26) was used for Suzuki coupling to give the title compound (28).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route O-(2,4-Dimethoxybenzyl)hydroxylamine, its application will become more common.
Reference:
Patent; S*BIO PTE LTD; WO2005/40161; (2005); A1;,
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