Synthetic Route of 6358-77-6, A common heterocyclic compound, 6358-77-6, name is 5-Bromo-2-methoxyaniline, molecular formula is C7H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of sodium nitrite (1 .78 g, 25.87 mmol) in water (5 mL) was slowly added to a cooled (-10 C) suspension of 5-bromo-2-methoxyaniline (5.0 g, 24.87 mmol) in 6N HCI aq. (13 mL) so as to keep the internal temperature below 0 C. The mixture was stirred for another 20 mm at 0 C, then a solution of stannous chloride dihydrate (14.1 g, 72.1 mmol) in conc. aq. HCI (25 mL) was added slowly. The reaction mixture was stirred an additional 1 .5 h at 0 C. The pH of the reaction mixture was carefully adjusted to -8 with sat. aq. NaHCO3. The mixture was extracted with EtOAc and the combined organic layers were dried over Na2SO4, filtered, and concentrated. The resulting residue was purified by trituration with pentane to give the title compound. MS (ESl+) m/z 217.0 (M(79Br)+H).
The synthetic route of 6358-77-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; ADAMS, Christopher; EHARA, Takeru; (134 pag.)WO2017/103888; (2017); A1;,
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