Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 767-91-9, name is 2′-Methoxyphenyl acetylene, A new synthetic method of this compound is introduced below., Recommanded Product: 2′-Methoxyphenyl acetylene
1-Ethynyl-2-methoxybenzene (2a, 265 mg, 2 mmol) and benzyl azide (266 mg, 2 mmol) were added to a 1 : 1 water-tert-butyl alcohol mixture (8 mL). A freshly prepared 1 M aqueous solution of sodium ascorbate (200 muL, 0.2 mmol) and an aqueous solution of CuSO 4 ¡¤ 5 H 2 O (65 muL, 5 mg, 0.02 mmol) were then added in succession, and the mixture was stirred for ~14 h at room temperature (TLC). The mixture was diluted with 30 mL of ice water and kept for 15 min in an ice bath, and the white precipitate was filtered off, thoroughly rinsed with cold water (2 ¡Á 15 mL), and dried under reduced pressure. Yield 474 mg (89%), off-white solid. 1 H NMR spectrum, delta, ppm: 8.11 s (1H), 7.58 d (2H, J = 7.4 Hz), 7.42 t (1H, J = 8.5 Hz), 7.34-7.28 m (3H), 7.16 d (1H, J = 7.1 Hz), 7.00-6.94 m (2H), 6.13 s (2H), 3.70 s (3H). 13 C NMR spectrum, delta C , ppm: 159.5, 139.5, 136.7, 131.6, 129.2, 128.5, 128.1, 126.5, 120.3, 109.2, 104.1, 56.1, 54.0. Mass spectrum: m/z 266.1214 [M + H] + . Calculated for C 16 H 16 N 3 O: 266.1217.
The synthetic route of 767-91-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Jabeen; Khera; Iqbal; Asgher; Russian Journal of Organic Chemistry; vol. 55; 9; (2019); p. 1416 – 1422; Zh. Org. Khim.;,
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