In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 398-62-9 as follows. Formula: C8H9FO2
To a suspension of sulfur trioxide N, N-dimethylformamide complex (4. [108G,] 27 mmol) in 1,2-dichloroethane was added 4-fluoroveratrole (3.49g, 22 mmol) dropwise. The mixture was slowly heated to [85C] in an oil bath. After 2.5h, the solids had dissolved to afford a golden yellow solution. A trace of starting material was still present and heating was continued for a further 4.5h. The oil bath was removed and thionyl chloride (1.95 mL, 27 mmol) added dropwise. The mixture was heated 4h at [85C] and allowed to cool to room temperature. The solution was poured into water and extracted with dichloromethane [(3X50] mL), the combined organics washed with water, dried over magnesium sulfate and evaporated. Remaining traces of N, N-dimethylformamide were removed azeotropically with toluene to afford the product as an off-white solid that was used without further purification.
According to the analysis of related databases, 398-62-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F.Hoffmann-la Roche AG; WO2004/13120; (2004); A1;,
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