These common heterocyclic compound, 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H11BrO2
[0917] To a cooled (0 C.) suspension ofdry NaH (0.512 g,21.4 mmol) in anhydrous DMF (10 mL) under an Argonatmosphere, a solutionof4-bromophenol (3.11 g, 17.8mmol)in anhydrous DMF (20 mL) was added dropwise over 2-3min. The mixture was stirred at oo C. for 10 min and thenallowed to warm to rt over 30 min. To the resulting whitesuspension was added 1-bromo-2-(2-methoxyethoxy)ethane(2.66 mL, 19.6 mmol) dropwise over 2 min and the mixturewas stirred at rt for 30 min and then at 65 C. for 1.5 h. Aftercooling to rt, the mixture was concentrated under reducedpressure to an oily suspension, diluted with brine (80 mL),and the mixture was extracted with EtOAc (3×60 mL). Thecombined extracts were washed with brine (2×25 mL), driedover Na2 S0 4 , filtered, and concentrated to give compound85a as a mobile, pale amber-colored oil, used inthe following reaction without further purification. Mass spectrum (LCMS,ESI pos.): Calcd. for C 11 H 15Br03 , 275.0/277.0 (M+H).found 275.2/277.1
The synthetic route of 1-Bromo-2-(2-methoxyethoxy)ethane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA, NV; Player, Mark R.; Meegalla, Sanath K.; Illig, Carl R.; Chen, Jinsheng; Wilson, Kenneth J.; Lee, Yu-Kai; Parks, Daniel J.; Huang, Hui; Patel, Sharmila; Lu, Tianbao; US2014/364414; (2014); A1;,
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