These common heterocyclic compound, 20469-65-2, name is 1-Bromo-3,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H9BrO2
The reaction mixture was prepared by adding 3,5dimethoxybromobenzene(1.74 g, 8.0 mmol, 1.0 eq) and catalyst PdCl2(PPh3) 2 (281 mg, 0.4 mmol, 0.05 eq) in a 100 mLSchlenk reaction flask, (20 ml), triethylamine (7 ml, 40 mmol, 5.0 eq) andcotaxyl borane (HBpin) were added to the reaction flask by means of a syringe, (3.5ml, 24.0mmol, 3.0eq), the reaction systemwas heated to 90 C and refluxed for 4 h. The reaction was cooled to room temperature and the reaction solution was pouredinto 20 ml of water to terminate the reaction. The aqueous phase was extracted with ethyl acetate several times. The organicphases were combined and washed once with saturated brine and water, dried over anhydrous magnesium sulfate, And theresulting product was recrystallized from nhexane/ ethyl acetate to give 1.8 g of a white solid in 85% yield. (S, 2H, benzene),6.90 (s, 1H, benzene), 3.84 (s, 6H, OCH3),1.33 (s, 12H, CH3).
The synthetic route of 1-Bromo-3,5-dimethoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY, CHINESE ACADEMY OF SCIENCES; LI YI, LI YI; HAO, QINGSHAN; CHEN, JINPING; ZENG, YI; YU, TIANJUN; (14 pag.)CN104557552; (2016); B;,
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