Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 701-07-5, name is 2-(2′-Bromophenoxy)propane, A new synthetic method of this compound is introduced below., Quality Control of 2-(2′-Bromophenoxy)propane
A mixture of 14 (0.114 g, 0.53 mmol), 19 (0.171 g, 0.79 mmol), PdCl2(PPh3)2 (0.037 g, 0.053 mmol) and TBAF (IM in THF) (2.65 mL, 2.65 mmol) were suspended in anhydrous THF (1 mL) and microwaved at 140 0C for 15 min. The reaction mixture was cooled to room temperature and diluted with DCM (30 mL). The mixture was filtered and concentrated in vacuo. The crude product was purified by HPLC to afford the title compound (0.09 g, 6%).[0209] 1H NMR (500 MHz, DMSO-J6): delta 1.37 (d, J = 6.1 Hz, 6H), 4.75-4.80 (m, IH), 6.67 (d, J = 3.5 Hz, IH), 7.01 (t, J = 7.4 Hz, IH), 7.17 (d, J = 8.4 Hz, IH), 7.44-7.47 (m, IH), 7.61- 7.63 (m, IH), 7.69 (d, J = 3.5 Hz, IH ), 8.75 (s, IH), 12.3 (s, IH)[0210] MS (ES+): m/z 278 (M+H)+
The synthetic route of 701-07-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
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